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Encyclopedia Britannica



GROUP XXV I

This article appears in Volume V21, Page 352 of the Encyclopedia Britannica.

Encyclopedia Britannica - Main :: GRA-GUI
GROUP XXV I . Antitoxins.These are substances which antago-
nize the toxins formed in the
body
  by pathogenic organisms, the toxins of snake venom and other
animal
  poisons, and vegetable toxins such as abrin, ricin, &c. A healthy person can be rendered insusceptible by gradually accustoming him to increasing doses of these poisons, and this
immunity
  is due to antitoxins which are found in the blood-serum and which are products of the blood cells. The nature of these antitoxic substances is not definitely known, but they combine with and destroy the poisons. In specific germ diseases a similar antitoxin forms, and in cases which recover it counteracts the toxin, while the germs are destroyed by the tissues. Antitoxins can be prepared by immunizing a large
animal
 , such as a
horse
 , by injecting gradually increasing doses of specific toxins into its subcutaneous
tissue
 . In due time the
horse
  is bled, the serum is filtered free of blood corpuscles, and then constitutes the
anti
 -toxic serum, which can be standardized to a certain potency. Such serums are injected subcutaneously in
diphtheria
 , tetanus, streptococcic infections, plague, snake-poisoning,
cholera
  and other similar diseases. They do not as a
rule
  harm healthy men even in large quantities, but when repeated they often cause serious symptoms due to the
body
  becoming more sensitive to the action of the horse-serum in which they are contained.


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