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Encyclopedia Britannica



FIBRIN, or FIBRINE

This article appears in Volume V10, Page 313 of the Encyclopedia Britannica.

Encyclopedia Britannica - Main :: FAT-FLA
FIBRIN, or FIBRINE , a protein formed by the action of the so-called fibrin-ferment on fibrinogen, a constituent of the blood-plasma of all vertebrates. This
change
  takes
place
  when blood leaves the arteries, and the fibrin thus formed occasions the clotting which ensues (see BLOOD). To obtain pure coagulated fibrin it is best to heat blood-plasma (preferably that of the
horse
 ) to 56 C. The usual method of beating a blood-
clot
  with twigs and removing the filamentous fibrin which attaches itself to them yields a very impure product containing haemoglobin and much globulin; moreover, it is very difficult to purify. Fibrin is a very voluminous, tough, strongly elastic, jelly-like substance; when denaturalized by heat,
alcohol
  or salts, it behaves as any other coagulated
albumin
 .


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